Cody Krivacic 
I am interested in understanding how best to apply our computational tools to protein engineering challenges. I am currently working on a computational method that re-positions amino acids of interest by manipulating the protein backbone and testing my designs experimentally. The ability to precisely define side-chain positions in protein binding sites will enable the engineering of proteins with altered specificity. 

Education

• Bachelor of Science, Biochemistry, UC Santa Barbara

Publications

1. Kung, P., Rui, E., Bergqvist, S., Bingham, P., Braganza, J., Collins, M., Cui, M., Diehl, W., Dinh, D., Fan, C., Fantin, V., Gukasyan, H., Hu, W., Huang, B., Kephart, S., Krivacic, C., Kumpf, R. A., Li, G., Maegley, K. A., McAlpine, I., Nguyen, L., Ornelas, M., Ryskin, M., Scales, S., Sutton, S., Tatlock, J., Verhelle, D., Wang, F., Wells, P., Wythes, M., Yamazaki, S., Yip, B., Yu, X., Zehnder, L., Zhang, W.-G., Rollins, R., and Edwards, M. Design and synthesis of pyridone containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of EZH2 inhibitors. J. Med. Chem. 2016,59(18):8306-25. doi: 10.1021/acs.jmedchem.6b00515
2. Maegley, K., Krivacic, C., Bingham, P., Liu, W., Brooun, A. Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay Protein Methyltransferase PRMT5. Assay Drug Dev. Tech. 2015, 13(4):1-7.
3. Kung, P., Huang, B., Zehnder, L., Tatlock, J., Bingham, P., Krivacic, C., Gajawala, K., Gajiwala, K., Diehl, W., Yu, X., Maegley, K. SAH derived potent and selective EZH2 inhibitors. Bioorg. Med. Chem. Lett. 2015, 25(7):1532-7.
4. Matje, D., Krivacic, C., Dahlquist, F., Reich, N. Distal structural elements coordinate a conserved base flipping network. Biochemistry. 2013, 52(10):1669-76. doi: 10.1021/bi301284f