Cody Krivacic
Graduate Student I am interested in understanding how best to apply our computational tools to protein engineering challenges. I am currently working on a computational method that re-positions amino acids of interest by manipulating the protein backbone and testing my designs experimentally. The ability to precisely define side-chain positions in protein binding sites will enable the engineering of proteins with altered specificity. Education
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Publications
- Kung, P., Rui, E., Bergqvist, S., Bingham, P., Braganza, J., Collins, M., Cui, M., Diehl, W., Dinh, D., Fan, C., Fantin, V., Gukasyan, H., Hu, W., Huang, B., Kephart, S., Krivacic, C., Kumpf, R. A., Li, G., Maegley, K. A., McAlpine, I., Nguyen, L., Ornelas, M., Ryskin, M., Scales, S., Sutton, S., Tatlock, J., Verhelle, D., Wang, F., Wells, P., Wythes, M., Yamazaki, S., Yip, B., Yu, X., Zehnder, L., Zhang, W.-G., Rollins, R., and Edwards, M. Design and synthesis of pyridone containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of EZH2 inhibitors. J. Med. Chem. 2016,59(18):8306-25. doi: 10.1021/acs.jmedchem.6b00515
- Maegley, K., Krivacic, C., Bingham, P., Liu, W., Brooun, A. Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay Protein Methyltransferase PRMT5. Assay Drug Dev. Tech. 2015, 13(4):1-7.
- Kung, P., Huang, B., Zehnder, L., Tatlock, J., Bingham, P., Krivacic, C., Gajawala, K., Gajiwala, K., Diehl, W., Yu, X., Maegley, K. SAH derived potent and selective EZH2 inhibitors. Bioorg. Med. Chem. Lett. 2015, 25(7):1532-7.
- Matje, D., Krivacic, C., Dahlquist, F., Reich, N. Distal structural elements coordinate a conserved base flipping network. Biochemistry. 2013, 52(10):1669-76. doi: 10.1021/bi301284f