Lu Hong
Postdoctoral Scholar
UCSF Profile

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I'm interested in designing biomolecular systems that function out of equilibrium. Specifically, my goal is to accelerate the period of the Kai oscillator, a post-translational circadian clock found in cyanobacteria.

Education

• Bachelor of Arts, Mathematics, Wabash College
• Ph.D., Biophysics, University of Chicago

Publications

1. Hong L, Lavrentovich DO, Chavan A, Leypunskiy E, Li E, Matthews C, LiWang A, Rust MJ, Dinner AR. Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock. Mol Syst Biol. 2020 Jun;16(6):e9355. doi: 10.15252/msb.20199355.
2. Antoszewski A, Feng CJ, Vani BP, Thiede EH, Hong L, Weare J, Tokmakoff A, Dinner AR. Insulin Dissociates by Diverse Mechanisms of Coupled Unfolding and Unbinding. J Phys Chem B. 2020 Jul 9;124(27):5571-5587. doi: 10.1021/acs.jpcb.0c03521. 
3. Hong L, Vani BP, Thiede EH, Rust MJ, Dinner AR. Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11475-E11484. doi: 10.1073/pnas.1812555115.
4. Boisclair Lachance JF, Webber JL, Hong L, Dinner AR, Rebay I. Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev. 2018 Mar 1;32(5-6):389-401. doi: 10.1101/gad.307132.117. 
5. Dahlberg PD, Boughter CT, Faruk NF, Hong L, Koh YH, Reyer MA, Shaiber A, Sherani A, Zhang J, Jureller JE, Hammond AT. A simple approach to spectrally resolved fluorescence and bright field microscopy over select regions of interest. Rev Sci Instrum. 2016 Nov;87(11):113704. doi: 10.1063/1.4967274.