Tina Perica
​Postdoctoral scholar
UCSF profile
tina.perica (at) ucsf.edu

​I am interested in studying the genotype-to-phenotype relationships by using the knowledge of protein structure and biophysics. I aim to do that by testing the quantitative effects of designed perturbations on the genetic interactions.

Sir Henry Wellcome Postdoctoral Fellow

Qualifications
  • Bachelor of Science, Molecular Biology, Zagreb University, Croatia
  • Ph.D., Molecular Biology, Cambridge University, UK
Publications
  1. Perica, T, Kondo, Y, Tiwari, SP, McLaughlin, SH, Kemplen, KR, Zhang, X, Steward, A, Reuter, N, Clarke, J, Teichmann, SA. Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science. 2014 Dec 19;346(6216):1254346. doi:10.1126/science.1254346
  2. Roller, M, Lucić, V, Nagy, I, Perica, T, Vlahoviček, K. Environmental shaping of codon usage and functional adaptation across microbial communities. Nucleic Acids Res 41(19):8842-52, 2013. doi: 10.1093/nar/gkt673
  3. Zhang, X, Perica, T, Teichmann, SA. Evolution of protein structures and interactions from the perspective of residue contact networks. Curr Opin Struct Biol , 2013. doi: 10.1016/j.sbi.2013.07.004
  4. Marsh, JA, Hernández, H, Hall, Z, Ahnert, SE, Perica, T, Robinson, C, Teichmann, SA. Protein Complexes Are under Evolutionary Selection to Assemble via Ordered Pathways. Cell 153(2):461-70, 2013. doi: 10.1016/j.cell.2013.02.044
  5. Perica, T, Marsh, JA, Sousa, FL, Natan, E, Colwell, LJ, Ahnert, SE, Teichmann, SA. The emergence of protein complexes: quaternary structure, dynamics and allostery. Biochem Soc Trans 40(3):475-91, 2012. doi: 10.1042/BST20120056
  6. Liberles, DA, Teichmann, SA, Bahar, I, Bastolla, U, Bloom, J, Bornberg-Bauer, E, Colwell, LJ, de Koning, APJ, Dokholyan, NV, Echave, J, Elofsson, A, Gerloff, DL, Goldstein, RA, Grahnen, JA, Holder, MT, Lakner, C, Lartillot, N, Lovell, SC, Naylor, G, Perica, T, Pollock, DD, Pupko, T, Regan, L, Roger, A, Rubinstein, N, Shakhnovich, E, Sjölander, K, Sunyaev, S, Teufel, AI, Thorne, JL, Thornton, JW, Weinreich, DM, Whelan, S. The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci 21(6):769-85, 2012. doi: 10.1002/pro.2071
  7. Perica, T, Chothia, C, Teichmann, SA. Evolution of oligomeric state through geometric coupling of protein interfaces. Proc Natl Acad Sci U S A 109(21):8127-32, 2012. doi: 10.1073/pnas.1120028109
  8. Perica, T, Chothia, C. Ubiquitin--molecular mechanisms for recognition of different structures. Curr Opin Struct Biol 20 (Nucleic acids / Sequences and topology)(3):367-76, 2010. doi: 10.1016/j.sbi.2010.03.007
  9. Crosetto, N, Bienko, M, Hibbert, RG, Perica, T, Ambrogio, C, Kensche, T, Hofmann, K, Sixma, TK, Dikic, I. Human Wrnip1 Is Localized in Replication Factories in a Ubiquitin-binding Zinc Finger-dependent Manner. J Biol Chem 283(50):35173-85, 2008. doi: 10.1074/jbc.M803219200