Tina Perica
​Postdoctoral scholar
UCSF profile

​I am interested in studying the genotype-to-phenotype relationships by using the knowledge of protein structure and biophysics. I aim to do that by testing the quantitative effects of designed perturbations on the genetic interactions.

Sir Henry Wellcome Postdoctoral Fellow

Qualifications
  • Bachelor of Science, Molecular Biology, Zagreb University, Croatia
  • Ph.D., Molecular Biology, Cambridge University, UK
Publications
  1. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9.
  2. Perica, T, Kondo, Y, Tiwari, SP, McLaughlin, SH, Kemplen, KR, Zhang, X, Steward, A, Reuter, N, Clarke, J, Teichmann, SA. Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science. 2014 Dec 19;346(6216):1254346. doi:10.1126/science.1254346
  3. Roller, M, Lucić, V, Nagy, I, Perica, T, Vlahoviček, K. Environmental shaping of codon usage and functional adaptation across microbial communities. Nucleic Acids Res 41(19):8842-52, 2013. doi: 10.1093/nar/gkt673
  4. Zhang, X, Perica, T, Teichmann, SA. Evolution of protein structures and interactions from the perspective of residue contact networks. Curr Opin Struct Biol , 2013. doi: 10.1016/j.sbi.2013.07.004
  5. Marsh, JA, Hernández, H, Hall, Z, Ahnert, SE, Perica, T, Robinson, C, Teichmann, SA. Protein Complexes Are under Evolutionary Selection to Assemble via Ordered Pathways. Cell 153(2):461-70, 2013. doi: 10.1016/j.cell.2013.02.044
  6. Perica, T, Marsh, JA, Sousa, FL, Natan, E, Colwell, LJ, Ahnert, SE, Teichmann, SA. The emergence of protein complexes: quaternary structure, dynamics and allostery. Biochem Soc Trans 40(3):475-91, 2012. doi: 10.1042/BST20120056
  7. Liberles, DA, Teichmann, SA, Bahar, I, Bastolla, U, Bloom, J, Bornberg-Bauer, E, Colwell, LJ, de Koning, APJ, Dokholyan, NV, Echave, J, Elofsson, A, Gerloff, DL, Goldstein, RA, Grahnen, JA, Holder, MT, Lakner, C, Lartillot, N, Lovell, SC, Naylor, G, Perica, T, Pollock, DD, Pupko, T, Regan, L, Roger, A, Rubinstein, N, Shakhnovich, E, Sjölander, K, Sunyaev, S, Teufel, AI, Thorne, JL, Thornton, JW, Weinreich, DM, Whelan, S. The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci 21(6):769-85, 2012. doi: 10.1002/pro.2071
  8. Perica, T, Chothia, C, Teichmann, SA. Evolution of oligomeric state through geometric coupling of protein interfaces. Proc Natl Acad Sci U S A 109(21):8127-32, 2012. doi: 10.1073/pnas.1120028109
  9. Perica, T, Chothia, C. Ubiquitin--molecular mechanisms for recognition of different structures. Curr Opin Struct Biol 20 (Nucleic acids / Sequences and topology)(3):367-76, 2010. doi: 10.1016/j.sbi.2010.03.007
  10. Crosetto, N, Bienko, M, Hibbert, RG, Perica, T, Ambrogio, C, Kensche, T, Hofmann, K, Sixma, TK, Dikic, I. Human Wrnip1 Is Localized in Replication Factories in a Ubiquitin-binding Zinc Finger-dependent Manner. J Biol Chem 283(50):35173-85, 2008. doi: 10.1074/jbc.M803219200