We are part of:
Department of Bioengineering and Therapeutic Sciences
California Institute for Quantitative Biosciences (QB3)
Integrative Program in Quantitative Biology
Graduate Group in Biophysics
Graduate Program in Bioinformatics
Graduate Program in Chemistry and Chemical Biology (CCB)
Synthetic Biology Engineering and Research Center (SynBERC)
We are located at:
1700 4th Street, Byers Hall 308E
UCSF MC 2530
San Francisco, CA 94143-2530
(CA 94158 for courier delivery)
301 (computational lab)
309 (experimental lab)
308E (Tanja Kortemme's office)

Group Photo

We are interested in how biological molecules communicate with each other, and how this communication encodes the processing of information. How do biomolecules recognize one another, and how do their interactions transduce signals? How do molecules build up "modules" that act as "adaptors", "switches" and feedback-loops? How are modules wired together into the networks responsible for regulation and decision processes observed in biology?

Computationally, we have developed a simple physical energy function for the prediction and design of protein-protein interactions, at the atomic level. Experimentally, we have applied this model to the computational redesign of a protein interface and have created an artificial DNA binding protein with new specificity. More recently, we have developed a computational strategy for the redesign of protein complexes to generate new pairs of interacting proteins.

We are now applying and extending our computational model at different "resolution", ranging from details of atom-atom interactions to cellular communication networks. We are aiming to develop more accurate methods to model the structural details of molecular interactions. Can new interactions and modules with defined properties be engineered? Ultimately we would like to apply computational and experimental methods to better understand how cellular processes are regulated by molecular communication.


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