Anum Azam Glasgow
​Postdoctoral Scholar
UCSF profile

Glasgow Lab website

I am interested in self-assembling systems and protein complexes. I am working on developing methods to design and experimentally test chemically inducible dimerization systems to produce versatile protein biosensors and improve our understanding of protein-ligand interfaces.

NIH NIGMS K99/R00 Postdoctoral Fellow
​UCSF IRACDA Postdoctoral Fellow
UCSF Chancellor's Postdoctoral Fellow
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Qualifications
  • Bachelor of Science, Biomedical Engineering, Johns Hopkins University
  • Ph.D., Bioengineering, UC Berkeley
Publications
  1. Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH Jr, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F; QCRG Structural Biology Consortium; DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA. Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure. 2023 Mar 2;31(3):253-264.e6. doi: 10.1016/j.str.2023.01.009. ​
  2. Glasgow, A., Hobbs, H.T., Perry, Z.R. et al. Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor. Nat Commun 14, 1179 (2023). https://doi.org/10.1038/s41467-023-36798-1
  3. Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer NS, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nature Biotechnology. 2021 Mar 25:1-8. https://doi.org/10.1038/s41587-021-00878-8.
  4. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ., Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020;117: 28046–28055. https://doi.org/10.1073/pnas.2016093117.
  5. Koehler Leman J, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J; RosettaCommons Consortium, Bystroff C, Schief W, Gront D, Schueler-Furman O, Baker D, Bradley P, Dunbrack R, Kortemme T, Leaver-Fay A, Strauss CEM, Meiler J, Kuhlman B, Gray JJ, Bonneau R. Better together: Elements of successful scientific software development in a distributed collaborative community. PLoS Comput Biol. 2020 May 4;16(5):e1007507. doi: 10.1371/journal.pcbi.1007507. ​
  6. Glasgow AA*, Huang YM*, Mandell DJ*, Thompson M, Ritterson R, Loshbaugh AL, Pellegrino J, Krivacic C, Pache RA, Barlow KA, Ollikainen N, Jeon D, Kelly MJS, Fraser JS, Kortemme T. Computational design of a modular protein sense-response system. Science. 2019 Nov 22;366(6468):1024-1028. doi: 10.1126/science.aax8780. *co-first author
  7. Glasgow A, Tullman-Ercek D. Type III Secretion Filaments as Templates for Metallic Nanostructure Synthesis. Methods Mol Biol. 1798:155-171. 2018  doi:10.1007/978-1-4939-7893-9_12. 
  8. Glasgow AA, Wong HT, Tullman-Ercek D. A Secretion-Amplification Role for Salmonella enterica Translocon Protein SipD. ACS Synth Biol. 6(6):1006-1015. 2017. doi:10.1021/acssynbio.6b00335.
  9. Azam, A, Tullman-Ercek, D. Type-III secretion filaments as scaffolds for inorganic nanostructures. J R Soc Interface. (114):20150938. 2016. doi:10.1098/rsif.2015.0938
  10. Azam, A, Li, C, Metcalf, KJ, Tullman-Ercek, D. Type III secretion as a generalizable strategy for the production of full-length biopolymer-forming proteins. Biotechnol Bioeng. 2015. doi:10.1002/bit.25656
  11. Metcalf, KJ, Finnerty, C, Azam, A, Valdivia, E, Tullman-Ercek, D. Using transcriptional control to increase titers of secreted heterologous proteins by the type III secretion system. Appl Environ Microbiol. 2014. 80(19):5927-34. doi:10.1128/AEM.01330-14
  12. Azam, A, Laflin, KE, Jamal, M, Fernandes, R, Gracias, DH. Self-folding micropatterned polymeric containers. Biomed Microdevices. 2011. 13(1):51-8. doi:10.1007/s10544-010-9470-x
  13. Cho, JH, Azam, A, Gracias, DH. Three dimensional nanofabrication using surface forces. Langmuir. 2010. 26(21):16534-9. doi:10.1021/la1013889 
  14. Filipiak, DJ,* Azam, A,* Leong, TG, Gracias, DH. Hierarchical self-assembly of complex polyhedral microcontainers. J Micromech Microeng. 2009. 19(7):1-6. doi:10.1088/0960-1317/19/7/075012 *co-first author
  15. Azam, A, Leong, TG, Zarafshar, AM, Gracias DH. Compactness determines the success of cube and octahedron self-assembly. PLoS One. 2009. 4(2):e4451. doi:10.1371/journal.pone.0004451