Lab members
​​​Tanja Kortemme
​
My main scientific interests range from the details of the physical interactions between atoms and molecules to the architecture and evolution of interaction networks in complex biological systems.

Education
  • Vordiplom (BS) Chemistry / Physical Chemistry, University of Hannover, Germany
  • Diplom (MSc) Biophysics, Stanford University / University of Hannover
  • Dr.rer.nat (Ph.D.) Biochemistry, EMBL Heidelberg / University of Hannover

Postdoctoral work
Computational and structural biology at EMBL Heidelberg and the Howard Hughes Medical Institute, University of Washington, Seattle.

Tanja's publications
Principal Investigator
 Bio, Profile

Postdoctoral scholars
Simon Kretschmer

​I am interested in developing protein-based biosensors for synthetic biology applications. In particular, I aim to design and experimentally characterize synthetic proteins that can sense and respond to small molecules of biomedical relevance.

PBBR Postdoctoral Independent Research Grant
Li Foundation Fellow

Education
  • Bachelor of Science, Chemistry and Biochemistry, Ludwig Maximilian University of Munich
  • Master of Science, Biochemistry, Ludwig Maximilian University of Munich
  • Dr.rer.nat. (Ph.D.), Biochemistry, Max-Planck-Institute of Biochemistry / Ludwig Maximilian University of Munich

Simon's publications
Postdoctoral Scholar
​Bio, Profile
Stephanie Crilly

I am interested in designing signaling proteins and systems, as well as developing tools to study endogenous signaling events.

Education​
  • Bachelor of Science, Microbiology, Penn State University
  • Ph.D., Cellular & Molecular Biology, University of Michigan

Stephanie's publications
Postdoctoral Scholar
​Bio, ​Profile
Giuseppe Cimicata

I’m interested in designing a reversible switching system triggered by protein-protein interactions. In parallel, I’m working on the reengineering and minimization of Cas9.

Education​
  • Bachelor of Science, Chemistry, University of Turin
  • Master of Science, Physical Chemistry, University of Turin
  • Ph.D., Chemistry, Weizmann Institute of Science

Giuseppe's publications
Postdoctoral Scholar
​Bio, ​Profile
Yilun Qi

I am fascinated by the relationship between protein structure and function. I hope to leverage protein design technologies to sample a variety of protein structures and functions.

Education​
  • Bachelor of Science, College of Life Sciences, Nankai University
  • Ph.D., Institutes of Biomedical Sciences, Fudan University

Yilun's publications
Postdoctoral Scholar
​Bio, ​Profile
Kosuke Seki

I'm interested in de novo design of ligand binding proteins and in high-throughput method development.

Education
  • Bachelor of Science, Chemical Engineering, University of California, Irvine
  • Ph.D., Chemical and Biological Engineering, Northwestern University

Kosuke's publications
Postdoctoral Scholar
​Bio
Meytal Radzinski

I am interested in studying the allosteric control of protein interaction networks and the layers of regulation that determine interaction specificity of protein switches under different cellular and organismal conditions.

Rothschild Fellow

Education
  • Bachelor of Science, Physics and Biology, Hebrew University of Jerusalem
  • Master of Science, Structural Biochemistry and Molecular Biology, Hebrew University of Jerusalem
  • Ph.D., Structural Biochemistry and Molecular Biology, Hebrew University of Jerusalem

Meytal's publications
Postdoctoral Scholar
​Bio

graduate students
Amy Guo

​I am interested in the designability of dynamic proteins and mini-proteins. Currently, I am working on creating mini-ACE2 designs to bind the SARS-CoV-2 spike protein.

NSF GRFP Fellow
UCSF Discovery Fellow

Education
  • Bachelor of Science, Bioengineering and Chemistry/Materials Science, UCLA

Amy's publications
 Graduate Student
Bio
Connor Galvin

​I am currently working on leveraging biological data to improve accuracy and efficiency in the computational design of de novo small molecule binding sites.

Education
  • Bachelor of Arts, Chemistry, New College of Florida

Connors's publications
 Graduate Student
Bio, Github
Dominic Grisingher

Protein switch design for protein-protein interactions.

ARCS Foundation Fellow

​Education
  • Bachelor of Science, Biochemistry, Arizona State University
  • Masters of Science, Biochemistry, Arizona State University

​Dom's publications
Graduate Student
Bio
Ben Orr
co-mentored by Mike Keiser

Protein design with deep learning.

NSF GRFP Fellow
Dr. Herbert Landahl Mathematical Biophysics Student Excellence Award
Mary Anne Koda-Kimble Seed Award for Innovation

Education
  • Bachelor of Science, Biochemistry, Tufts University

Ben's publications
Graduate Student
Bio, GitHub
Deniz Akpinaroglu

Design of small-molecule binding proteins with deep learning.

​​NSF GRFP Fellow

Education
  • Bachelor of Science, Bioengineering, UC Merced

Deniz's publications​
Graduate Student
Bio, GitHub
Philipp Huettemann

Designing de novo signaling systems.

Education
  • Bachelor of Science, Biochemistry, University of Michigan, Ann Arbor

Philipp's publications​
Graduate Student
Bio
Catherine Kuhn

Designing de novo switches with deep learning.

Education
  • Bachelor of Arts, Biochemistry, Washington University in St. Louis

Catherine's publications​
Graduate Student
Bio, GitHub
Radhika Dalal

I am using de novo design to control protein-DNA interactions.

​​NSF GRFP Fellow

Education
  • Bachelor of Science, Cell Biology & Biochemistry, University of Washington
​
Radhika's publications​
Graduate Student
Bio
Jon Zhang
co-mentored by Margaux Pinney

I am leveraging approaches in high throughput biochemistry and machine learning to develop models of allosteric coupling in molecular switches.

Education
  • Bachelor of Science, Biochemistry, University of Washington
​
Jon's publications​
Graduate Student
Bio
Maple Chen

I'm interested in de novo protein design for systems, signaling, or medical applications.

​​NSF GRFP Fellow
​
Education
  • Bachelor of Science, Biomedical Engineering, Cornell University

Maple's publications
Graduate Student
Bio
Alex Li
co-mentored by Margaux Pinney

Deep learning for de novo enzyme design.
​
​​NSF GRFP Fellow
​
Education
  • Bachelor of Science, Chemistry, Massachusetts Institute of Technology

Alex's publications
Graduate Student
Bio, GitHub, Website

Lab technicians
Eleanor Zhu

I am generally interested in protein design and testing de novo proteins using high throughput methods.
​​
Education
  • Bachelor of Science, Chemical Biology, University of California, Berkeley
  • Bachelor of Arts, Applied Mathematics, University of California, Berkeley

Eleanor's publications
Lab Technician
Bio

Junior Specialists
Rochel Munitz

I am interested in combining machine learning and experimental approaches to accelerate de novo protein design, particularly of protein switches.
​​
NSF Rosetta Commons RaMP Research Fellow

Education
  • Bachelor of Science, Computer Science and Honors Biology, Touro University
​
Rochel's publications
Junior Specialist​
Bio