KORTEMME LAB @ UCSF
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Lab members

​​​Tanja Kortemme
​
My main scientific interests range from the details of the physical interactions between atoms and molecules to the architecture and evolution of interaction networks in complex biological systems.

Education
  • Vordiplom (BS) Chemistry / Physical Chemistry, University of Hannover, Germany
  • Diplom (MSc) Biophysics, Stanford University / University of Hannover
  • Dr.rer.nat (Ph.D.) Biochemistry, EMBL Heidelberg / University of Hannover

Postdoctoral work
Computational and structural biology at EMBL Heidelberg and the Howard Hughes Medical Institute, University of Washington, Seattle.

Tanja's publications
Tanja Kortemme
Principal Investigator
 Bio, Profile

Postdoctoral scholars


Simon Kretschmer
I am interested in developing protein-based biosensors for synthetic biology applications. In particular, I aim to design and experimentally characterize synthetic proteins that can sense and respond to small molecules of biomedical relevance.

PBBR Postdoctoral Independent Research Grant
Li Foundation Fellow

Education
  • Bachelor of Science, Chemistry and Biochemistry, Ludwig Maximilian University of Munich
  • Master of Science, Biochemistry, Ludwig Maximilian University of Munich
  • Dr.rer.nat. (Ph.D.), Biochemistry, Max-Planck-Institute of Biochemistry / Ludwig Maximilian University of Munich

Simon's publications
Simon Kretschmer
Postdoctoral Scholar
​
Bio, Profile
Lu Hong
I'm interested in designing biomolecular systems that function out of equilibrium. Specifically, my goal is to accelerate the period of the Kai oscillator, a post-translational circadian clock found in cyanobacteria.

Education
  • Bachelor of Arts, Mathematics, Wabash College
  • Ph.D., Biophysics, University of Chicago

Lu's publications
Simon Kretschmer
Postdoctoral Scholar
​
Bio, ​Profile
Robert Alberstein
I am interested in the construction of biomolecular machines, motors, and switches, which carry out their functions through structural changes coupled to thermodynamic driving forces (e.g. chemical gradients, nucleotide hydrolysis). My research is focused on understanding and developing methods for the design of conformationally pliable systems that can be switched/driven between states via energy input from chemical fuel or light.

Arnold O. Beckman Postdoctoral Fellow
​
Education
  • Bachelor of Science, Biological Sciences - Neuroscience Track, Carnegie Mellon University
  • Ph.D., Chemistry, University of California, San Diego

Robert's publications
Simon Kretschmer
Postdoctoral Scholar
​
Bio
Stephanie Crilly

I am interested in designing signaling proteins and systems, as well as developing tools to study endogenous signaling events.

Education​
  • Bachelor of Science, Microbiology, Penn State University
  • PhD, Cellular & Molecular Biology, University of Michigan

Stephanie's publications
Simon Kretschmer
Postdoctoral Scholar
​
Bio, ​Profile

graduate students


Amy Guo
I am interested in the designability of dynamic proteins and mini-proteins. Currently, I am working on creating mini-ACE2 designs to bind the SARS-CoV-2 spike protein.

NSF GRFP Fellow
UCSF Discovery Fellow

Education
  • Bachelor of Science, Bioengineering and Chemistry/Materials Science, UCLA

Amy's publications
Cody Krivacic
 Graduate Student
Bio
Connor Galvin
I am currently working on leveraging biological data to improve accuracy and efficiency in the computational design of de novo small molecule binding sites.

Education
  • Bachelor of Arts, Chemistry, New College of Florida

Connors's publications
Cody Krivacic
 Graduate Student
Bio, Github
Cody Krivacic 
I am interested in understanding how best to apply our computational tools to protein engineering challenges. I am currently working on a computational method that re-positions amino acids of interest by manipulating the protein backbone and testing my designs experimentally. The ability to precisely define side-chain positions in protein binding sites will enable the engineering of proteins with altered specificity. 

Education
  • Bachelor of Science, Biochemistry, UC Santa Barbara

Cody's publications
Cody Krivacic
 Graduate Student
Bio, GitHub
​​Chris Mathy
I'm interested in how organisms finely control system-wide behavior by tuning protein conformation, dynamics, and interactions. My current work is on the small GTPase Ran/Gsp1, looking into how it's key partners regulate Gsp1 cycling to allow for different behavior in several cellular pathways.
​
UCSF Discovery Fellow
​
Education
  • Bachelor of Science, Bioengineering, Stanford University

Chris's publications
Chris Mathy
Graduate Student
Bio, GitHub
Dominic Grisingher

Protein switch design for protein-protein interactions.

ARCS Foundation Fellow

​Education
  • Bachelor of Science, Biochemistry, Arizona State University
  • Masters of Science, Biochemistry, Arizona State University

​Dom's publications
Chris Mathy
Graduate Student
Bio, GitHub
Ben Orr
co-mentored by Mike Keiser

Protein design with deep learning.

NSF GRFP Fellow
Dr. Herbert Landahl Mathematical Biophysics Student Excellence Award
Mary Anne Koda-Kimble Seed Award for Innovation


Education
  • Bachelor of Science, Biochemistry, Tufts University

Ben's publications
Chris Mathy
Graduate Student
Bio, GitHub
Deniz Akpinaroglu

Design of small-molecule binding proteins with deep learning.

​​NSF GRFP Fellow

Education
  • Bachelor of Science, Bioengineering, UC Merced

Deniz's publications​
Chris Mathy
Graduate Student
Bio, GitHub
  • Home
  • Research
    • Computational Protein Design and Modeling
    • Control of Biological Systems
    • Evolution of Structure, Function, and Network Interactions
  • People
    • Current Members
    • Lab Alumni
    • Join the Lab
  • Publications
  • News
  • Gallery
  • Contact
    • Meetings
    • Directions
  • Rosetta
  • Link Page
  • Our Wiki
  • Benchmarks