Lab members
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Tanja Kortemme
My main scientific interests range from the details of the physical interactions between atoms and molecules to the architecture and evolution of interaction networks in complex biological systems. Education
Postdoctoral work Computational and structural biology at EMBL Heidelberg and the Howard Hughes Medical Institute, University of Washington, Seattle. Tanja's publications |
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Postdoctoral scholars
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Tina Perica
I am interested in studying the genotype-to-phenotype relationships by using the knowledge of protein structure and biophysics. I aim to do that by testing the quantitative effects of designed perturbations on the genetic interactions. Sir Henry Wellcome Postdoctoral Fellow Education
Tina's publications |
#Post-Dog
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Anum Azam Glasgow
I am interested in understanding the molecular basis for signal transduction in proteins, and designing new allosteric proteins. NIH NIGMS K99/R00 Postdoctoral Fellow Education
Anum's publications |
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Simon Kretschmer
I am interested in developing protein-based biosensors for synthetic biology applications. In particular, I aim to design and experimentally characterize synthetic proteins that can sense and respond to small molecules of biomedical relevance. Education
Simon's publications |
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Lu Hong
I'm interested in designing biomolecular systems that function out of equilibrium. Specifically, my goal is to accelerate the period of the Kai oscillator, a post-translational circadian clock found in cyanobacteria. Education
Lu's publications |
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Robert Alberstein
I am interested in the construction of biomolecular machines, motors, and switches, which carry out their functions through structural changes coupled to thermodynamic driving forces (e.g. chemical gradients, nucleotide hydrolysis). My research is focused on understanding and developing methods for the design of conformationally pliable systems that can be switched/driven between states via energy input from chemical fuel or light. Education
Robert's publications |
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Benjamin Jagger
My interests are focused on using computational modeling and simulation-based techniques to inform the design of enzymes. Specifically, I am interested in improving the therapeutic potential of Cas9 systems by designing properties such as reduced size, self-delivery ability, cell targeting specificity, and reduced immunogenicity. Education
Benjamin's publications |
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graduate students
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Amy Guo
I am interested in the designability of dynamic proteins and mini-proteins. Currently, I am working on creating mini-ACE2 designs to bind the SARS-CoV-2 spike protein. Education
Amy's publications |
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Connor Galvin
I am currently working on leveraging biological data to improve accuracy and efficiency in the computational design of de novo small molecule binding sites. Education
Connors's publications |
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Cody Krivacic
I am interested in understanding how best to apply our computational tools to protein engineering challenges. I am currently working on a computational method that re-positions amino acids of interest by manipulating the protein backbone and testing my designs experimentally. The ability to precisely define side-chain positions in protein binding sites will enable the engineering of proteins with altered specificity. Education
Cody's publications |
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Chris Mathy
I'm interested in how organisms finely control system-wide behavior by tuning of protein structure, dynamics, and interactions. My current work is on the small GTPase Ran/Gsp1, looking into how it's key partners regulate Gsp1 cycling to allow for different behavior in several cellular pathways. Education
Chris's publications |
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staff
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Yang (Sunny) Zhang
Education
Sunny's publications |
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