Lab members
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Tanja Kortemme
My main scientific interests range from the details of the physical interactions between atoms and molecules to the architecture and evolution of interaction networks in complex biological systems. Education
Postdoctoral work Computational and structural biology at EMBL Heidelberg and the Howard Hughes Medical Institute, University of Washington, Seattle. Tanja's publications |
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Postdoctoral scholars
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Simon Kretschmer
I am interested in developing protein-based biosensors for synthetic biology applications. In particular, I aim to design and experimentally characterize synthetic proteins that can sense and respond to small molecules of biomedical relevance. PBBR Postdoctoral Independent Research Grant Li Foundation Fellow Education
Simon's publications |
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Lu Hong
I'm interested in designing biomolecular systems that function out of equilibrium. Specifically, my goal is to accelerate the period of the Kai oscillator, a post-translational circadian clock found in cyanobacteria. Education
Lu's publications |
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Robert Alberstein
I am interested in the construction of biomolecular machines, motors, and switches, which carry out their functions through structural changes coupled to thermodynamic driving forces (e.g. chemical gradients, nucleotide hydrolysis). My research is focused on understanding and developing methods for the design of conformationally pliable systems that can be switched/driven between states via energy input from chemical fuel or light. Arnold O. Beckman Postdoctoral Fellow Education
Robert's publications |
Postdoctoral Scholar
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Stephanie Crilly
I am interested in designing signaling proteins and systems, as well as developing tools to study endogenous signaling events. Education
Stephanie's publications |
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graduate students
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Amy Guo
I am interested in the designability of dynamic proteins and mini-proteins. Currently, I am working on creating mini-ACE2 designs to bind the SARS-CoV-2 spike protein. NSF GRFP Fellow UCSF Discovery Fellow Education
Amy's publications |
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Connor Galvin
I am currently working on leveraging biological data to improve accuracy and efficiency in the computational design of de novo small molecule binding sites. Education
Connors's publications |
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Cody Krivacic
I am interested in understanding how best to apply our computational tools to protein engineering challenges. I am currently working on a computational method that re-positions amino acids of interest by manipulating the protein backbone and testing my designs experimentally. The ability to precisely define side-chain positions in protein binding sites will enable the engineering of proteins with altered specificity. Education
Cody's publications |
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Chris Mathy
I'm interested in how organisms finely control system-wide behavior by tuning protein conformation, dynamics, and interactions. My current work is on the small GTPase Ran/Gsp1, looking into how it's key partners regulate Gsp1 cycling to allow for different behavior in several cellular pathways. UCSF Discovery Fellow Education
Chris's publications |
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Dominic Grisingher
Protein switch design for protein-protein interactions. ARCS Foundation Fellow Education
Dom's publications |
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Ben Orr
co-mentored by Mike Keiser Protein design with deep learning. NSF GRFP Fellow Dr. Herbert Landahl Mathematical Biophysics Student Excellence Award Mary Anne Koda-Kimble Seed Award for Innovation Education
Ben's publications |
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Deniz Akpinaroglu
Design of small-molecule binding proteins with deep learning. NSF GRFP Fellow Education
Deniz's publications |
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Philipp Huettemann
Designing de novo signaling systems. Education
Philipp's publications |
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Catherine Kuhn
Designing de novo switches with deep learning. Education
Catherine's publications |
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