Kosuke Seki
Postdoctoral Scholar

I'm interested in de novo design of ligand binding proteins and in high-throughput method development.

Education

• Bachelor of Science, Chemical Engineering, University of California, Irvine
• Ph.D., Chemical and Biological Engineering, Northwestern University

Publications

1. Seki, K.; Galindo, J. L.; Karim, A. S.; Jewett, M. C. A Cell-Free Gene Expression Platform for Discovering and Characterizing Stop Codon Suppressing tRNAs. ACS Chem. Biol. 2023. https://doi.org/10.1021/acschembio.3c00051.
2. Zubi, Y. S.; Seki, K.; Li, Y.; Hunt, A. C.; Liu, B.; Roux, B.; Jewett, M. C.; Lewis, J. C. Metal-Responsive Regulation of Enzyme Catalysis Using Genetically Encoded Chemical Switches. Nat. Commun. 2022, 13 (1), 1–10. https://doi.org/10.1038/s41467-022-29239-y.
3. Perez, J. G.; Carlson, E. D.; Weisser, O.; Kofman, C.; Seki, K.; Des Soye, B. J.; Karim, A. S.; Jewett, M. C. Improving Genomically Recoded Escherichia Coli to Produce Proteins Containing Non-Canonical Amino Acids. Biotechnol. J. 2022, 17 (4), e2100330. https://doi.org/10.1002/biot.202100330.
4. Black, W. B.; King, E.; Wang, Y.; Jenic, A.; Rowley, A. T.; Seki, K.; Luo, R.; Li, H. Engineering a Coenzyme A Detour To Expand the Product Scope and Enhance the Selectivity of the Ehrlich Pathway. ACS Synth. Biol. 2018, 7 (12), 2758–2764. https://doi.org/10.1021/acssynbio.8b00358.
5. Kim, J.; Copeland, C. E.; Seki, K.; Vögeli, B.; Kwon, Y.-C. Tuning the Cell-Free Protein Synthesis System for Biomanufacturing of Monomeric Human Filaggrin. Front Bioeng Biotechnol 2020, 8 (October), 590341. https://doi.org/10.3389/fbioe.2020.590341.​

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