Giuseppe Cimicata
Postdoctoral Scholar

I’m interested in designing a reversible switching system triggered by protein-protein interactions. In parallel, I’m working on the reengineering and minimization of Cas9.

Education​
  • Bachelor of Science, Chemistry, University of Turin
  • Master of Science, Physical Chemistry, University of Turin
  • Ph.D., Chemistry, Weizmann Institute of Science
Publications
  1. Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis. mBio. 2022 04 26; 13(2):e0030622. Cimicata G, Fridkin G, Bose T, Eyal Z, Halfon Y, Breiner-Goldstein E, Fox T, Zimmerman E, Bashan A, de Val N, Wlodawer A, Yonath A. PMID: 35348349; PMCID: PMC9040758.
  2. Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia. Nucleic Acids Res. 2022 02 22; 50(3):1770-1782. Hiregange DG, Rivalta A, Bose T, Breiner-Goldstein E, Samiya S, Cimicata G, Kulakova L, Zimmerman E, Bashan A, Herzberg O, Yonath A. PMID: 35100413; PMCID: PMC8860606.
  3. Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance. Proc Natl Acad Sci U S A. 2021 11 16; 118(46). König G, Sokkar P, Pryk N, Heinrich S, Möller D, Cimicata G, Matzov D, Dietze P, Thiel W, Bashan A, Bandow JE, Zuegg J, Yonath A, Schulz F, Sanchez-Garcia E. PMID: 34750269; PMCID: PMC8609559.
  4. Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. Nucleic Acids Res. 2021 09 20; 49(16):9560-9573. Breiner-Goldstein E, Eyal Z, Matzov D, Halfon Y, Cimicata G, Baum M, Rokney A, Ezernitchi AV, Lowell AN, Schmidt JJ, Rozenberg H, Zimmerman E, Bashan A, Valinsky L, Anzai Y, Sherman DH, Yonath A. PMID: 34417608; PMCID: PMC8450085.
  5. Working at the membrane interface: Ligand-induced changes in dynamic conformation and oligomeric structure in human aromatase. Biotechnol Appl Biochem. 2018 Jan; 65(1):46-53. Di Nardo G, Cimicata G, Baravalle R, Dell'Angelo V, Ciaramella A, Catucci G, Ugliengo P, Gilardi G. PMID: 28926141.
  6. Ribosomal Antibiotics: Contemporary Challenges. Antibiotics (Basel). 2016 Jun 29; 5(3). Auerbach-Nevo T, Baram D, Bashan A, Belousoff M, Breiner E, Davidovich C, Cimicata G, Eyal Z, Halfon Y, Krupkin M, Matzov D, Metz M, Rufayda M, Peretz M, Pick O, Pyetan E, Rozenberg H, Shalev-Benami M, Wekselman I, Zarivach R, Zimmerman E, Assis N, Bloch J, Israeli H, Kalaora R, Lim L, Sade-Falk O, Shapira T, Taha-Salaime L, Tang H, Yonath A. PMID: 27367739; PMCID: PMC5039520.