​​Chris Mathy
Graduate Student

I'm interested in how organisms finely control system-wide behavior by tuning of protein structure, dynamics, and interactions. My current work is on the small GTPase Ran/Gsp1, looking into how its key partners regulate Gsp1 cycling to allow for different behavior in several cellular pathways.

Education
  • Bachelor of Science, Bioengineering, Stanford
Publications
  1. Mathy CJP, Kortemme T. Emerging maps of allosteric regulation in cellular networks. Curr Opin Struct Biol. 2023 Jun;80:102602. doi: 10.1016/j.sbi.2023.102602. 
  2. Mathy, C. J. P., Mishra, P., Flynn, J. M., Perica, T., Mavor, D., Bolon, D. N. A., & Kortemme, T. (2023). A complete allosteric map of a GTPase switch in its native cellular network. Cell Systems, 14(3), 237-246.e7. https://doi.org/10.1016/j.cels.2023.01.003
  3. Baker JJ, Mathy, CJP, & Schaletzky J. A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design. PLoS Computational Biology, 2021 17(12), e1009624. https://doi.org/10.1371/journal.pcbi.1009624
  4. ​Perica T*, Mathy CJP*, Xu J, Jang GΜ, Zhang Y, Kaake R, Ollikainen N, Braberg H, Swaney DL, Lambright DG, Kelly MJS, Krogan NJ, Kortemme T. Systems-level effects of allosteric perturbations to a model molecular switch. Nature. 2021 Oct 13:1-6. https://doi.org/10.1038/s41586-021-03982-6. *co-first author
  5. Bouhaddou M et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Jun 28:S0092-8674(20)30811-4. doi: 10.1016/j.cell.2020.06.034.
  6. Gordon DE et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9.