Cody Krivacic 
Graduate Student


​I am interested in understanding how best to apply our computational tools to protein engineering challenges. I am currently working on a computational method that re-positions amino acids of interest by manipulating the protein backbone and testing my designs experimentally. The ability to precisely define side-chain positions in protein binding sites will enable the engineering of proteins with altered specificity. 

Education
  • Bachelor of Science, Biochemistry, UC Santa Barbara
Publications
  1. Krivacic C*, Kundert K*, Pan X*, Pache RA*, Liu L, Conchúir SO, Jeliazkov JR, Gray JJ, Thompson MC, Fraser JS, & Kortemme T.  Accurate positioning of functional residues with robotics-inspired computational protein design. Proc Natl Acad Sci U S A, 2022;119(11), e2115480119. https://doi.org/10.1073/pnas.2115480119 *co-first author
  2. Glasgow AA*, Huang YM*, Mandell DJ*, Thompson M, Ritterson R, Loshbaugh AL, Pellegrino J, Krivacic C, Pache RA, Barlow KA, Ollikainen N, Jeon D, Kelly MJS, Fraser JS, Kortemme T. Computational design of a modular protein sense-response system. Science. 2019 Nov 22;366(6468):1024-1028. doi: 10.1126/science.aax8780. *co-first author
  3. Kung, P., Rui, E., Bergqvist, S., Bingham, P., Braganza, J., Collins, M., Cui, M., Diehl, W., Dinh, D., Fan, C., Fantin, V., Gukasyan, H., Hu, W., Huang, B., Kephart, S., Krivacic, C., Kumpf, R. A., Li, G., Maegley, K. A., McAlpine, I., Nguyen, L., Ornelas, M., Ryskin, M., Scales, S., Sutton, S., Tatlock, J., Verhelle, D., Wang, F., Wells, P., Wythes, M., Yamazaki, S., Yip, B., Yu, X., Zehnder, L., Zhang, W.-G., Rollins, R., and Edwards, M. Design and synthesis of pyridone containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of EZH2 inhibitors. J. Med. Chem. 2016,59(18):8306-25. doi: 10.1021/acs.jmedchem.6b00515
  4. Maegley, K., Krivacic, C., Bingham, P., Liu, W., Brooun, A. Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay Protein Methyltransferase PRMT5. Assay Drug Dev. Tech. 2015, 13(4):1-7.
  5. Kung, P., Huang, B., Zehnder, L., Tatlock, J., Bingham, P., Krivacic, C., Gajawala, K., Gajiwala, K., Diehl, W., Yu, X., Maegley, K. SAH derived potent and selective EZH2 inhibitors. Bioorg. Med. Chem. Lett. 2015, 25(7):1532-7.
  6. Matje, D., Krivacic, C., Dahlquist, F., Reich, N. Distal structural elements coordinate a conserved base flipping network. Biochemistry. 2013, 52(10):1669-76. doi: 10.1021/bi301284f​