Simon Kretschmer
Postdoctoral Scholar
UCSF Profile

PBBR Postdoctoral Independent Research Grant
Li Foundation Fellow

Education
  • Bachelor of Science, Chemistry and Biochemistry, Ludwig Maximilian University of Munich
  • Master of Science, Biochemistry, Ludwig Maximilian University of Munich
  • Dr.rer.nat. (Ph.D.), Biochemistry, Max-Planck-Institute of Biochemistry / Ludwig Maximilian University of Munich
Publications
  1. Kretschmer, S., Perry, N., Zhang, Y., and Kortemme, T.. Multi-input Drug-Controlled Switches of Mammalian Gene Expression Based on Engineered Nuclear Hormone Receptors. 2023 ACS Synthetic Biology, Article ASAP. https://doi.org/10.1021/acssynbio.3c00080
  2. Kretschmer S & Kortemme T. Advances in the Computational Design of Small-Molecule-Controlled Protein-Based Circuits for Synthetic Biology. 2022 Proceedings of the IEEE. https://doi.org/10.1109/JPROC.2022.3157898
  3. Kretschmer S, Heermann T, Tassinari A, Glock P, & Schwille P. Increasing MinD’s Membrane Affinity Yields Standing Wave Oscillations and Functional Gradients on Flat Membranes. 2021 ACS synthetic biology, 10(5), 939-949. https://doi.org/10.1021/acssynbio.0c00604
  4. Fu M, Franquelim HG, Kretschmer S, & Schwille P. Non‐Equilibrium Large‐Scale Membrane Transformations Driven by MinDE Biochemical Reaction Cycles. 2021 Angewandte Chemie, 133(12), 6570-6576. https://doi.org/10.1002/anie.202015184
  5. Kretschmer S*, Ganzinger KA*, Franquelim HG, & Schwille P. Synthetic cell division via membrane-transforming molecular assemblies. 2019 Bmc Biology, 17(1), 1-10. https://doi.org/10.1186/s12915-019-0665-1
  6. Glock P, Ramm B, Heermann T, Kretschmer S, Schweizer J, Mücksch J, Alagöz G, Schwille P. Stationary patterns in a two-protein reaction-diffusion system. ACS Synth Biol. 2018 Dec 20. doi: 10.1021/acssynbio.8b00415.
  7. Denk J*, Kretschmer S*, Halatek J, Hartl C, Schwille P, Frey E. MinE conformational switching confers robustness on self-organized Min protein patterns. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4553-4558. doi: 10.1073/pnas.1719801115. *co-first author
  8. Kretschmer S, Harrington L, Schwille P. Reverse and forward engineering of protein pattern formation. Philos Trans R Soc Lond B Biol Sci. 2018 May 26;373(1747). pii: 20170104. doi: 10.1098/rstb.2017.0104.
  9. Frey, E., Halatek, J., Kretschmer, S., Schwille, P. (2018) Protein Pattern Formation, Book chapter in Physics of Biological Membranes, Edited by P. Bassereau and P. C. A.  Sens (Springer-Verlag GmbH, Heidelberg), 229-260
  10. Glock P, Broichhagen J, Kretschmer S, Blumhardt P, Mücksch J, Trauner D, Schwille P. Optical Control of a Biological Reaction-Diffusion System. Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2362-2366. doi: 10.1002/anie.201712002.
  11. Kretschmer S, Zieske K, Schwille P. Large-scale modulation of reconstituted Min protein patterns and gradients by defined mutations in MinE's membrane targeting sequence. PLoS One. 2017 Jun 16;12(6):e0179582. doi: 10.1371/journal.pone.0179582.
  12. Trussart M, Yus E, Martinez S, Baù D, Tahara YO, Pengo T, Widjaja M, Kretschmer S, Swoger J, Djordjevic S, Turnbull L, Whitchurch C, Miyata M, Marti-Renom MA, Lluch-Senar M, Serrano L. Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae. Nat Commun. 2017 Mar 8;8:14665. doi: 10.1038/ncomms14665.
  13. Kretschmer S, Schwille P. Pattern formation on membranes and its role in bacterial cell division. Curr Opin Cell Biol. 2016 Feb;38:52-9. doi: 10.1016/j.ceb.2016.02.005.
  14. Kretschmer, S., and Schwille, P. (2015) Rekonstitution biologischer Selbstorganisation in vitro. BIOspektrum 21, 148-150
  15. Kretschmer S, Schwille P. Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies. Life (Basel). 2014 Dec 11;4(4):915-28. doi: 10.3390/life4040915.
  16. O'Donnelly K, Zhao G, Patel P, Butt MS, Mak LH, Kretschmer S, Woscholski R, Barter LM. Isolation and kinetic characterisation of hydrophobically distinct populations of form I Rubisco. Plant Methods. 2014 Jun 12;10:17. doi: 10.1186/1746-4811-10-17.