Tina Perica
​Postdoctoral scholar
UCSF profile

​I am interested in studying the genotype-to-phenotype relationships by using the knowledge of protein structure and biophysics. I aim to do that by testing the quantitative effects of designed perturbations on the genetic interactions.

Sir Henry Wellcome Postdoctoral Fellow

Qualifications
  • Bachelor of Science, Molecular Biology, Zagreb University, Croatia
  • Ph.D., Molecular Biology, Cambridge University, UK
Publications
  1. Mathy, CJP, Mishra P, Flynn JM, Perica T, Mavor D, Bolon DNA, & Kortemme T. Complete mutational mapping of a GTPase switch in vivo reveals novel allosteric regulation. 2022 bioRxiv https://doi.org/10.1101/2022.04.13.488230
  2. Perica T*, Mathy CJP*, Xu J, Jang GΜ, Zhang Y, Kaake R, Ollikainen N, Braberg H, Swaney DL, Lambright DG, Kelly MJS, Krogan NJ, Kortemme T. Systems-level effects of allosteric perturbations to a model molecular switch. Nature. 2021 Oct 13:1-6. https://doi.org/10.1038/s41586-021-03982-6. *co-first author
  3. Gordon DE et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9.
  4. Perica, T, Kondo, Y, Tiwari, SP, McLaughlin, SH, Kemplen, KR, Zhang, X, Steward, A, Reuter, N, Clarke, J, Teichmann, SA. Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science. 2014 Dec 19;346(6216):1254346. doi:10.1126/science.1254346
  5. Roller, M, Lucić, V, Nagy, I, Perica, T, Vlahoviček, K. Environmental shaping of codon usage and functional adaptation across microbial communities. Nucleic Acids Res 41(19):8842-52, 2013. doi: 10.1093/nar/gkt673
  6. Zhang, X, Perica, T, Teichmann, SA. Evolution of protein structures and interactions from the perspective of residue contact networks. Curr Opin Struct Biol , 2013. doi: 10.1016/j.sbi.2013.07.004
  7. Marsh, JA, Hernández, H, Hall, Z, Ahnert, SE, Perica, T, Robinson, C, Teichmann, SA. Protein Complexes Are under Evolutionary Selection to Assemble via Ordered Pathways. Cell 153(2):461-70, 2013. doi: 10.1016/j.cell.2013.02.044
  8. Perica, T, Marsh, JA, Sousa, FL, Natan, E, Colwell, LJ, Ahnert, SE, Teichmann, SA. The emergence of protein complexes: quaternary structure, dynamics and allostery. Biochem Soc Trans 40(3):475-91, 2012. doi: 10.1042/BST20120056
  9. Liberles, DA, Teichmann, SA, Bahar, I, Bastolla, U, Bloom, J, Bornberg-Bauer, E, Colwell, LJ, de Koning, APJ, Dokholyan, NV, Echave, J, Elofsson, A, Gerloff, DL, Goldstein, RA, Grahnen, JA, Holder, MT, Lakner, C, Lartillot, N, Lovell, SC, Naylor, G, Perica, T, Pollock, DD, Pupko, T, Regan, L, Roger, A, Rubinstein, N, Shakhnovich, E, Sjölander, K, Sunyaev, S, Teufel, AI, Thorne, JL, Thornton, JW, Weinreich, DM, Whelan, S. The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci 21(6):769-85, 2012. doi: 10.1002/pro.2071
  10. Perica, T, Chothia, C, Teichmann, SA. Evolution of oligomeric state through geometric coupling of protein interfaces. Proc Natl Acad Sci U S A 109(21):8127-32, 2012. doi: 10.1073/pnas.1120028109
  11. Perica, T, Chothia, C. Ubiquitin--molecular mechanisms for recognition of different structures. Curr Opin Struct Biol 20 (Nucleic acids / Sequences and topology)(3):367-76, 2010. doi: 10.1016/j.sbi.2010.03.007
  12. Crosetto, N, Bienko, M, Hibbert, RG, Perica, T, Ambrogio, C, Kensche, T, Hofmann, K, Sixma, TK, Dikic, I. Human Wrnip1 Is Localized in Replication Factories in a Ubiquitin-binding Zinc Finger-dependent Manner. J Biol Chem 283(50):35173-85, 2008. doi: 10.1074/jbc.M803219200