Yang (Sunny) Zhang
Specialist

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Education
  • Bachelor of Science, Chemistry, Peking University, Beijing, China
  • Ph.D., Biochemistry, Boston College
Publications
  1. Perica T*, Mathy CJP*, Xu J, Jang GΜ, Zhang Y, Kaake R, Ollikainen N, Braberg H, Swaney DL, Lambright DG, Kelly MJS, Krogan NJ, Kortemme T. Systems-level effects of allosteric perturbations to a model molecular switch. Nature. 2021 Oct 13:1-6. https://doi.org/10.1038/s41586-021-03982-6. *co-first author
  2. Gordon DE et al. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 Dec 4;370(6521). https://doi.org/10.1126/science.abe9403. 
  3. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ., Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020;117: 28046–28055. https://doi.org/10.1073/pnas.2016093117.
  4. Pan X, Thompson M, Zhang Y, Lin L, Fraser JS, Kelly MJ, Kortemme T. Expanding the space of protein geometries by computational design of de novo fold families. Science. Aug 28;2020 369(6507):1132-1136. doi: 10.1126/science.abc0881.
  5. Thompson S, Zhang Y, Ingle C, Reynolds KA, Kortemme T. Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme. Elife. 2020 Jul 23;9:e53476. doi:10.7554/eLife.53476.
  6. Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD. Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica. Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):560-5. doi: 10.1107/S2053230X1500179X. Epub 2015 Apr 21. PubMed PMID: 25945709; PubMed Central PMCID: PMC4427165.
  7. Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM,Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, GardbergAS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D,Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb). 2015 Mar;95(2):142-8. doi: 10.1016/j.tube.2014.12.003.
  8. Zhang Y, Edwards TE, Begley DW, Abramov A, Thompkins KB, Ferrell M, Guo WJ, Phan I, Olsen C, Napuli A, Sankaran B, Stacy R, Van Voorhis WC, Stewart LJ, Myler PJ. Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1100-5. doi: 10.1107/S1744309111012541. 
  9. Guild K, Zhang Y, Stacy R, Mundt E, Benbow S, Green A, Myler PJ. Wheat germ cell-free expression system as a pathway to improve protein yield and solubility for the SSGCID pipeline. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1027-31. doi: 10.1107/S1744309111032143.
  10. Ferrell M, Abendroth J, Zhang Y, Sankaran B, Edwards TE, Staker BL, Van Voorhis WC, Stewart LJ, Myler PJ. Structure of aldose reductase from Giardia lamblia. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1113-7. doi: 10.1107/S1744309111030879.
  11. Phan I, Subramanian S, Olsen C, Edwards TE, Guo W, Zhang Y, Van Voorhis WC, Stewart LJ, Myler PJ. Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1123-8. doi: 10.1107/S174430911102690X. 
  12. Abendroth J, McCormick MS, Edwards TE, Staker B, Loewen R, Gifford M, Rifkin J, Mayer C, Guo W, Zhang Y, Myler P, Kelley A, Analau E, Hewitt SN, Napuli AJ, Kuhn P, Ruth RD, Stewart LJ. X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source. J Struct Funct Genomics. 2010 Mar;11(1):91-100. doi: 10.1007/s10969-010-9087-6.
  13. Olson P, Zhang Y, Olsen D, Owens A, Cohen P, Nguyen K, Ye JJ, Bass S, Mascarenhas D. High-level expression of eukaryotic polypeptides from bacterial chromosomes. Protein Expr Purif. 1998 Nov;14(2):160-6.
  14. Zhang Y, Olsen DR, Nguyen KB, Olson PS, Rhodes ET, Mascarenhas D. Expression of eukaryotic proteins in soluble form in Escherichia coli. Protein Expr Purif. 1998 Mar;12(2):159-65.
  15. Thorstenson YR, Zhang Y, Olson PS, Mascarenhas D. Leaderless polypeptides efficiently extracted from whole cells by osmotic shock. J Bacteriol. 1997 Sep;179(17):5333-9.
  16. Zhang Y, Kantrowitz ER. Probing the regulatory site of Escherichia coli aspartate transcarbamoylase by site-specific mutagenesis. Biochemistry. 1992 Jan 28;31(3):792-8.
  17. Zhang Y, Kantrowitz ER. The synergistic inhibition of Escherichia coli aspartate carbamoyltransferase by UTP in the presence of CTP is due to the binding of UTP to the low affinity CTP sites. J Biol Chem. 1991 Nov 25;266(33):22154-8.
  18. Stebbins JW, Zhang Y, Kantrowitz ER. Importance of residues Arg-167 and Gln-231 in both the allosteric and catalytic mechanisms of Escherichia coli aspartate transcarbamoylase. Biochemistry. 1990 Apr 24;29(16):3821-7.
  19. Zhang Y, Kantrowitz ER. Lysine-60 in the regulatory chain of Escherichia coli aspartate transcarbamoylase is important for the discrimination between CTP and ATP. Biochemistry. 1989 Sep 5;28(18):7313-8.
  20. Zhang Y, Ladjimi MM, Kantrowitz ER. Site-directed mutagenesis of a residue located in the regulatory site of Escherichia coli aspartate transcarbamoylase. Involvement of lysine 94 in effector binding and the allosteric mechanism. J Biol Chem. 1988 Jan 25;263(3):1320-4.